Elevated Serum Transferrin Saturation and Mortality

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Elevated serum transferrin saturation and mortality.

BACKGROUND A large proportion of US adults have elevated transferrin saturation, an indicator of a predisposition for iron overload. The purpose of this study was to evaluate the relationship between elevated serum transferrin saturation and mortality. METHODS This cohort study was conducted using data from the First Health and Nutrition Examination Survey 1 (1971-1974) (NHANES I) merged with...

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Transferrin saturation and mortality.

Ellervik and colleagues (1 ) recently reported a positive association between transferrin saturation (TS) and mortality. Several questions arise from this observation: Is the association due to all causes of iron overload or to hereditary hemochromatosis only? Does the study underestimate the true association? And, is mortality due to variation in iron, transferrin, or both? We have relevant da...

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The mortality risk of elevated serum transferrin saturation and consumption of dietary iron.

BACKGROUND Recent data shows an increased mortality risk associated with elevated transferrin saturation. Because ingestion of dietary iron may contribute to iron overload in persons with elevated transferrin saturation, we investigated the relationship between elevated transferrin saturation, ingestion of dietary iron and red meat, and mortality. METHODS This 12-year cohort study used data f...

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Total Mortality by Elevated Transferrin Saturation in Patients With Diabetes

OBJECTIVE It is not known to what extent iron overload predicts prognosis in patients with diabetes after diagnosis or whether iron overload is a risk factor independent of the HFE genotype. We investigated total and cause-specific mortality according to increased transferrin saturation (≥ 50 vs. <50%), whether mortality is driven by the HFE genotype, and whether early measurement of transferri...

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Elevated Transferrin Saturation and Risk of Diabetes

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ژورنال

عنوان ژورنال: The Annals of Family Medicine

سال: 2004

ISSN: 1544-1709,1544-1717

DOI: 10.1370/afm.25